What is oxytocin receptor polymorphism?
Oxytocin is a pituitary neuropeptide that affects social behaviour. Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) have been shown to explain some variability in social abilities in control populations.
What is rs53576?
0.4128. Max Magnitude. 2.8. rs53576 is a silent G to A change in the oxytocin receptor (OXTR) gene. Studies have demonstrated that individuals with the G allele are more empathetic, feel less lonely, employ more sensitive parenting techniques, and have lower rates of autism (discussed in [PMID 20724662 ])
What is oxytocin receptor antagonist?
Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Inhibition of PG synthesis/activity is used to delay preterm birth.
What hormone increases oxytocin?
Uterus. Oxytocin receptor expression in the myometrium increases only after progesterone withdrawal in the rat (156,490), so progesterone prevents premature contractile responses to oxytocin.
What does the OXTR gene do?
The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. In humans, the oxytocin receptor is encoded by the OXTR gene which has been localized to human chromosome 3p25.
What is rs1815739?
active profile. Mechanism: This SNP, in the ACTN3 gene, encodes a premature stop codon in a muscle protein called alpha-actinin-3. The polymorphism alters position 577 of the alpha-actinin-3 protein.
What do oxytocin receptors do?
The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. OXTR is also associated with the central nervous system. The gene is believed to play a major role in social, cognitive, and emotional behavior.
What inhibits oxytocin release?
A number of factors can inhibit oxytocin release, among them acute stress. For example, oxytocin neurons are repressed by catecholamines, which are released from the adrenal gland in response to many types of stress, including fright.
What drug blocks oxytocin?
The anti-nociceptive effect of OT is blocked by naloxone and is related to potentiation of GABA interneurons in the dorsal horn (20). Axons of hypothalamic OT neurons in the central amygdala reduce neural output from the central amygdala via activation of GABA interneurons (21).
What is the relationship between oxytocin and OXTR?
Oxytocin receptors are synthesised by the Oxytocin Receptor (OXTR) gene, which expresses both centrally in the brain and within peripheral organs. In this way, OXT has both peripheral and central functions. OXTR is located on human chromosome 3p25.
How does oxytocin receptor work?
Activation of oxytocin receptor causes myometrial contractions by increasing intracellular Ca+2 and production of prostaglandins. Since oxytocin induces contractions, the inhibition of its action has been a target in the management of preterm labor.
What is the role of the resultoxtr oxytocin receptor?
5021 – Gene ResultOXTR oxytocin receptor [ (human)] The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the effects of oxytocin receptor polymorphisms?
In major depressive disorder, oxytocin receptor gene polymorphisms effects hippocampal volume. There is an association between OXTR rs53576 polymorphisms and empathic responses; this association is modulated by sadistic contexts.
How does the OXTR gene affect social interaction?
Findings highlight the influences of the OXTR gene on adaptive interpersonal interactions, especially when individuals face changing social situations. The present results indicate that OXTR genotype moderates the strength of the association between social support from the baby’s father and Postpartum depression symptoms.
How does the oxytocin receptor affect cellular senescence?
Oxytocin alleviates cellular senescence through oxytocin receptor-mediated extracellular signal-regulated kinase/Nrf2 signalling. Oxytocin and oxytocin receptor alterations, decreased survival, and increased chemoresistance in patients with pancreatic cancer.