How many Stereogenic centers are there in aliskiren?
four stereogenic centers
there are four stereogenic centers in aliskiren.
How many chiral centers does aliskiren have?
Chemistry: Aliskiren is a single diastereomer having 4 chiral centers, all S-configured.
What is the mechanism of action of aliskiren?
Aliskiren is the first and only approved direct renin inhibitor. The mechanism of action of this drug is unique in that it blocks the RAAS by binding to a pocket in renin itself, preventing it from cleaving angiotensinogen to angiotensin I.
What is the classification of aliskiren?
Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.
What is the brand name for aliskiren?
Aliskiren (brand names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. It is used for essential (primary) hypertension.
Is aliskiren an ACE inhibitor?
Aliskiren is an orally-active, nonpeptidic, direct inhibitor of renin which simultaneously reduces angiotensin I, angiotensin II and plasma renin activity (PRA). This is the main point of action of aliskiren, making it completely different from ACE inhibitors and ARBs.
Is aliskiren renin inhibitor?
Aliskiren is an orally effective direct renin inhibitor that blocks the generation of angiotensin I from angiotensinogen, the rate limiting step of RAAS activation. Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibitors and ARBs.
Can aliskiren cause hyperkalemia?
The concomitant use of aliskiren with other agents acting on the RAAS such as ACEIs or ARBs is associated with an increased risk of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy.
Is aliskiren the same as Tekturna?
PDL BioPharma has announced the availability of an authorized generic version of Tekturna (aliskiren hemifumarate; Noden Pharma). Tekturna, a direct renin inhibitor, is indicated for the treatment of hypertension in patients aged 6 years and older.
Can aliskiren be taken with Losartan?
Using aliskiren together with losartan may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.
What is the medical term aliskiren?
What is aliskiren? Aliskiren is blood pressure medicine. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure. Aliskiren is used to treat high blood pressure (hypertension).
What drugs have aliskiren?
Aliskiren is found in the following medications:
- Amturnide (aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide)
- Tekturna (aliskiren hemifumarate)
- Tekturna HCT (aliskiren hemifumarate and hydrochlorothiazide)
- Tekamlo (aliskiren hemifumarate and amlodipine besylate)