Can carboplatin be given in normal saline?
Effective 01 June 2013, the standard default diluent solution for carboplatin has been changed to 0.9% sodium chloride (normal saline [NS]) from dextrose 5% (D5W) in all BCCA chemotherapy protocols and pre-printed orders.
Is carboplatin hard on kidneys?
Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin. The affected individuals usually have nonoliguric renal failure with a urine output of more than a liter per day.
How long does carboplatin stay in your body?
The chemotherapy itself stays in the body within 2 -3 days of treatment but there are short-term and long-term side effects that patients may experience. Not all patients will experience all side effects but many will experience at least a few.
Does carboplatin contain platinum?
Platinum-based drugs, such as cisplatin, (trade name Platinol) and carboplatin (trade name Paraplatin) have the chemical element platinum as part of their molecular structure.
Is carboplatin platinum-based?
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events).
What is the pH of carboplatin?
Carboplatin is a crystalline powder with the molecular formula of C6H12N2O4Pt and a molecular weight of 371.25. It is soluble in water at a rate of approximately 14 mg/mL, Approved v1.0 Page 2 2 of 21 and the pH of a 1% solution is 5 to 7. It is virtually insoluble in ethanol, acetone, and dimethylacetamide.
How is carboplatin dosed?
-This drug is usually administered by an infusion lasting 15 minutes or longer. -No pre- or post-treatment hydration or forced diuresis is required. -The target AUC of 4 to 6 mg/mL/min using single agent carboplatin appears to provide the most appropriate dose range in previously treated patients.
Does carboplatin affect the heart?
Cardiovascular events. Although infrequent, heart failure, blood clots and strokes have been reported with Carboplatin use. Less than 1% were life-threatening. Allergic reaction may occur.
Will I lose my hair on carboplatin?
Your hair may get thinner. But you are unlikely to lose all the hair from your head. Hair loss usually starts after your first or second treatment. It is almost always temporary, and your hair will usually grow back after treatment finishes.