Why is pethidine not given IV?

Why is pethidine not given IV?

Adverse effects Pethidine should not be given IV as it significantly depresses myocardial contractility and causes histamine release. Vomiting is rarely seen after administration and it does not cause excitement in cats or horses.

How is pethidine injected?

Pethidine Injection may be administered by injection into a muscle (intramuscular), or into the tissue just below the skin (subcutaneous) or by slow injection into the vein (intravenous).

How many MLS is pethidine?

Pethidine 50mg/ml & 100mg/2ml Solution for Injection.

Do you dilute IV Demerol?

Inject IV slowly, preferably as a diluted solution. Continuous intravenous infusion: Dilute solution (e.g., 1 mg/mL) for continuous IV infusion. IM administration is preferred when repeated doses are required.

How do you dilute pethidine?

It is recommended, therefore, that: (1) Pethidine hydrochloride when given intravenously should always be diluted in either normal saline or distilled water, 10 mg. per ml. being a convenient compromise.

Does pethidine slow labour?

Pethidine can slow down your labour. If given shortly before birth it can affect your baby’s breathing and feeding and make them less alert. If necessary your baby can have an injection to reverse the effects of the drug.

Does pethidine slow Labour?

What IV drugs need to be diluted?

The following medications require dilution: ranitidine, famotidine, pantoprazole, lorazepam, promethazine. In certain settings, the following drugs require dilution in order to give them IV push: Digoxin Immune FAB, ephedrine, phentolamine, phenylephrine, phenytoin, vitamin K, magnesium sulfate.

Is pethidine bad for baby?

As Pethidine is an opiate it will cross the placenta and a small amount will pass through to your baby. This can sometimes make babies sleepy when born if it’s given later on in labour, a reversal drug for your baby would then be required should this happen.

When do you give pethidine in labour?

There is no limit to how late in labour pethidine can be given. If the patient needs analgesia she should be given the appropriate dose. However, if she receives pethidine within 6 hours of delivery, the infant may have respiratory depression at birth. Pethidine may be given late in labour if needed.

Can a Pethidine injection be administered intravenously?

Pethidine Injection may be administered by subcutaneous, intramuscular or slow intravenous injection. 4.3 Contraindications • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Use of pethidine should be avoided in patients with diabetic acidosis where there is danger of coma.

How often should you take pethidine as an adult?

Adult: 50-100 mg via IM or SC inj, may be repeated at intervals of 1-3 hours as needed. Max: 400 mg in 24 hours. Adult: 25-150 mg via IM or SC inj 4 hourly as needed; may also be given via slow IV inj at a dose of 25-50 mg, repeated 4 hourly as needed.

Is it safe to use pethidine in infants?

Pethidine should be used with caution or in reduced doses in patients with myasthenia gravis.Pethidine should only be used with caution and in reduced dosage in neonates and premature infants, elderly and debilitated patients and in patients with head injuries, severe hepatic or renal impairment.

What are some of the side effects of pethidine?

Significant: Adrenal insufficiency, CNS depression, constipation, severe hypotension (e.g. orthostatic hypotension, syncope), spasm of sphincter of Oddi. Cardiac disorders: Bradycardia, palpitation, tachycardia.

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