What was arsphenamine used for?
History of Microbiology His search for such compounds led to the discovery of several drugs useful in the treatment of protozoal and spirochetal diseases between 1905 and 1915. The arsenical compound, arsphenamine (salvarsan, compound 606), was used to treat syphilis until the advent of penicillin.
How do magic bullets work medicine?
From Behring’s work, Ehrlich understood that antibodies produced in the blood could attack invading pathogens without any harmful effect on the body. He speculated that these antibodies act as bullets fired from a gun to target specific microbes.
Is arsphenamine still used?
Uses. In the past, arsenic compounds have been used as medicines, including arsphenamine and neosalvasan which were indicated for syphilis and trypanosomiasis but have now been supplanted by modern antibiotics.
What did Ehrlich and Hata realize when they discovered arsphenamine?
When he tested compound No. 606, Hata observed that it had truly notable curative properties against syphilis. Ehrlich had just discovered the magic bullet he had so intently been seeking: arsphenamine.
What disease was Salvarsan used for?
In 1910, Paul Ehrlich introduced the arsenic-based drug Salvarsan as a remedy for syphilis, a sexually transmitted disease that was exacting a toll on public health similar to that of HIV in recent decades.
What is the magic bullet approach?
“The conventional ‘magic bullet’ approach to drug development is focused on identifying single molecules that kill disease organisms by disrupting single targets in single artificial cell lines.
Why are monoclonal antibodies called magic bullets?
They have been hailed as the prototypical magic bullet drug because of their inherent capacity for specificity. Consequently, monoclonal antibodies have many possible therapeutic applications with varied potential for successful outcome.
When was Arsphenamine invented?
The first of these was arsphenamine, which was developed in 1910 by the German medical scientist Paul Ehrlich for the treatment of syphilis.
What are the contributions of Paul Ehrlich in microbiology?
The new method Ehrlich had introduced formed the basis of the Ziehl-Neelsen acid-fast staining reaction that was developed later and is still in use today . Paul Ehrlich also contributed to the development of staining reactions through which other bacteria and microbes were detected and classified.