What is the most common complication with ADT?
Weight gain and increased body fat mass are common complications of ADT. This weight gain coupled with low activity levels secondary to fatigue and changes in lipid levels may increase the risk of cardiovascular toxicities.
What are the side effects of ADT?
Because androgens affect many other organs besides the prostate, ADT can have a wide range of side effects (4, 27), including:
- loss of interest in sex (lowered libido)
- erectile dysfunction.
- hot flashes.
- loss of bone density.
- bone fractures.
- loss of muscle mass and physical strength.
- changes in blood lipids.
- insulin resistance.
What is a common side effect in men of the anti hormone based therapy for metastatic prostate cancer?
Difficulty getting or keeping an erection is a common side effect of hormone therapy for prostate cancer. This is also called impotence. Hormone therapy lowers the amount of testosterone in your body or stops your body from making testosterone.
What is androgen-independent prostate cancer?
Androgen-independent prostate cancer (AIPC) is an untreatable form of prostate cancer in which the normal dependence on androgens for growth and survival has been bypassed. AIPC is selected for by androgen ablation therapy.
Do anti androgens cause erectile dysfunction?
Loss of libido and erectile dysfunction (ED) are well-known side effects of this treatment and are usually attributed to the decrease in testosterone levels.
Which side effect indicates excessive androgen therapy?
A significant side effect associated with ADT is loss of bone density or bone mass. Bone loss increases the risk of osteoporosis, bone fracture, pain, hospitalization, and immobility, and increases medical costs.
How long can a man stay on hormone therapy for prostate cancer?
Locally advanced prostate cancer You may be offered hormone therapy for up to six months before radiotherapy. And you may continue to have hormone therapy during and after your radiotherapy, for up to three years. Some men might have hormone therapy on its own if radiotherapy or surgery aren’t suitable for them.
How does prostate cancer become androgen independent?
Almost all prostate cancers begin in an androgen-dependent state, so androgen deprivation therapy is administered and results in improved clinical outcomes. However, over time, some cancerous cells are able to survive and grow during this treatment, resulting in androgen-independent prostate cancer.
What does androgen independent mean?
Listen to pronunciation. (AN-droh-jen…) Describes the ability of tumor cells to grow in the absence of androgens (hormones that promote the development and maintenance of male sex characteristics).
Is there a cure for androgen independent prostate cancer?
For the sake of clarity, this article will use androgen-independent prostate cancer. Hormone therapy, a mainstay of prostate cancer treatment for more than 60 years, has been shown to shrink tumors, reduce pain associated with bone metastases, and extend survival.
How does androgen independent prostate cancer usually spread?
OH: Androgen-independent prostate cancer is very heterogeneous, and we don’t fully understand the biology of it, but it does tend to present in different ways. It commonly spreads to the bones, but it may also spread to other organs or the lymph nodes.
Are there any side effects to hormone therapy for prostate cancer?
Estrogens avoid the bone loss seen with other kinds of hormone therapy, but they increase the risk of cardiovascular side effects, including heart attacks and strokes. Because of these side effects, estrogens are rarely used today as hormone therapy for prostate cancer.
Are there any androgen synthesis inhibitors for prostate cancer?
Three androgen synthesis inhibitors are approved in the United States: abiraterone (Yonsa, Zytiga), ketoconazole, and aminoglutethimide. All are given as pills to be swallowed. Abiraterone is approved in combination with prednisone to treat metastatic prostate cancer, both castration-sensitive and castration-resistant.