What is the difference between hemoglobin C and E?
Hemoglobin C in high amounts means hemoglobin C disease, which causes anemia and an enlarged spleen. Hemoglobin types S and C mean hemoglobin S-C disease, which causes a mild or moderate form of sickle cell disease. Hemoglobin E in low amounts means the presence of hemoglobin E trait.
What is Haemoglobin C disease?
Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.
What is hemoglobin type e?
Hemoglobin E trait is an inherited blood disorder. That means it is passed down through your parent’s genes. It leads to an abnormal form of hemoglobin that may cause mild anemia. It occurs most often in people of Southeast Asian descent.
Is hemoglobin C disease Microcytic?
The anemia is usually mild but can be severe. The peripheral smear is microcytic, with frequent target cells, spherocytes, and, rarely, crystal-containing red blood cells (RBCs).
How is hemoglobin C diagnosed?
The disorder is often found during newborn screening blood tests. Blood tests for hemoglobin C disease include: Complete blood count (CBC). A complete blood count checks the red and white blood cells, blood clotting cells (platelets), and sometimes, young red blood cells (reticulocytes).
What is homozygous hemoglobin E?
Homozygous Hemoglobin E (phenotype: FEE in infants and EE in adults) Homozygous hemoglobin E results when the gene for hemoglobin E is inherited from both parents. A mild thalassemia phenotype develops in the first few months of life as the amount of fetal hemoglobin decreases and hemoglobin E increases.
Is Hb E disease thalassemia?
Hemoglobin E/beta thalassemia disease is a lifelong disease that can cause serious health problems. If both parents have hemoglobin E trait, there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin E disease. People with hemoglobin E may have health problems and mild anemia.
What is heterozygous Haemoglobin E disease?
Heterozygous AE occurs when the gene for hemoglobin E is inherited from one parent and the gene for hemoglobin A from the other. This is called hemoglobin E trait, and it is not a disease. People who have hemoglobin E trait (heterozygous) are asymptomatic and their state does not usually result in health problems.
What is Hb E beta thalassemia?
Hemoglobin E – beta-thalassemia (HbE – BT) is a form of beta-thalassemia (see this term) that results in a mild to severe clinical presentation ranging from a condition indistinguishable from beta-thalassemia major to a mild form of beta-thalassemia intermedia (see these terms).
How to tell if you have hemoglobin C disease?
Hemoglobin C disease is suspected in all patients with a family history and evidence of a hemolytic anemia, particularly in adults with splenomegaly. The anemia is usually mild but can be severe. The smear is microcytic, with frequent target cells, spherocytes, and, rarely, crystal-containing red blood cells (RBCs). Nucleated RBCs may be present.
What are the symptoms of hemoglobin E disease?
Most people with hemoglobin E (HbE) disease do not have any symptoms. Some people may have mild anemia and microcytosis (a red blood cell size smaller than the normal range). [1] [3] [4] Do you have updated information on this disease?
What are the symptoms of homozygous Hemoglobin C?
Symptoms and signs. Hemoglobin C causes mild disease and does not cause clinical symptoms. Under homozygous condition (HbC/HbC) there can be a mild to moderate enlargement of the spleen, splenomegaly, as well as hemolytic anemia (which is the form of anemia due to abnormal breakdown of red blood cells prematurely) and sometimes jaundice.
What happens to hemoglobin C in the peripheral smear?
The peripheral smear demonstrates mostly target cells, occasional hemoglobin C crystals, and only a few sickle cells. However, persons with hemoglobin SC disease (HbSC) have more significant retinopathy, ischemic necrosis of bone, and priapism than those with pure SS disease.