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What Does Cell Signaling Technology do?

What Does Cell Signaling Technology do?

Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study the cell signaling pathways that impact human health.

What is a PDL1 antibody?

PDL1 is a protein that helps keep immune cells from attacking nonharmful cells in the body. Normally, the immune system fights foreign substances like viruses and bacteria, and not your own healthy cells. Some cancer cells have high amounts of PDL1.

What are cell signaling pathways?

Listen to pronunciation. (SIG-nuh-ling …) Describes a series of chemical reactions in which a group of molecules in a cell work together to control a cell function, such as cell division or cell death.

How do cells communicate over short distances?

Cells communicate over short distances by using local regulators that target cells in the vicinity of the emitting cell (the cell that releases the chemical).

What is the difference between atezolizumab and Pembrolizumab?

For overall patients, pembrolizumab had significantly superior OS (hazard ratio (HR) with 95% confidence interval, 0.67, 0.47–0.94; P = 0.02) and numerically better PFS (HR, 0.79, 0.60–1.04; P = 0.10) than atezolizumab, while they had similar ORR, all cause AE and grade 3–5 AE.

What do PD-1 antibodies do?

PD-1 is a checkpoint protein on immune cells called T cells. It normally acts as a type of “off switch” that helps keep the T cells from attacking other cells in the body. It does this when it attaches to PD-L1, a protein on some normal (and cancer) cells.

What is Ser473?

Phosphorylation of serine 473 (Ser473) residue is a target of the mTOR complex 2 (mTORC2) [17] and DNA-dependent protein kinase (DNA-PK) [18]. Maximal AKT activity is dependent on the phosphorylation status of both Thr308 and Ser473 residues [15].

What is the purpose of a signaling pathway?

Describes a series of chemical reactions in which a group of molecules in a cell work together to control a cell function, such as cell division or cell death.

Why are PD-1 and PD-L1 antibodies important?

Accordingly, PD-1 and PD-L1 have garnered much attention for their roles in tumor immunology and as immune-based therapeutic targets (4,5). Demonstrates consistent, reliable results in immunohistochemistry, flow cytometry, western blotting and immunoprecipitation.

Where is PD-L1 located on the cell surface?

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PD-L1 protein. Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses.

What is the ligand for programmed cell death 1?

Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation.

How does PD-L1 interact with T cells?

PD-L1 is upregulated in several tumor types and contributes to the malignancy of these cancers by interacting with PD-1 and inhibiting T cell activation. In this way, the tumors avoid detection and destruction by the immune system (1-3).

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