What does CDC6 stand for?
cell division cycle 6
The CDC6 gene provides instructions for making a protein that is important in the copying of a cell’s DNA before the cell divides (a process known as DNA replication). The protein produced from this gene, called cell division cycle 6 or CDC6, is one of a group of proteins known as the pre-replication complex.
Is CDC6 a protein?
Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase.
Where is CDC6 located?
Actually, CDC6 is conserved in every eukaryotic organism, and CDC6-related genes are found in Archaea (14). The human CDC6 gene is located at chromosome 17q21. 3 and its expression is controlled by the E2F/retinoblastoma transcription factors that regulate S-phase-promoting genes (15–17).
Is Cdc6 a transcription factor?
The human CDC6 gene is located at chromosome 17q21. 3 and its expression is controlled by the E2F family of transcription factors that regulate S-phase-promoting genes.
Why is Cdc6 important in helicase loading?
ATP binding and hydrolysis play critical roles during helicase loading. Cdc6 is activated to bind and hydrolyze ATP when it associates with origin-bound ORC, and this hydrolysis event is required to observe Mcm2–7 loading (Perkins and Diffley 1998; Randell et al. 2006).
What is the function of Cdc6 during S phase?
Cdc6 is also required during S phase to allow Chk1 activation in response to replication fork inhibition, though ORC-dependent chromatin binding is not required for this function.
Is Cdc6 an enzyme?
However, the mutant Cdc6 enzymes remain stuck to the complex, which blocks DNA copying. In cells, if the mutant Cdc6 enzymes are deliberately destroyed after the MCM complex binds to DNA, DNA copying proceeds normally. This implies that Cdc6 inhibits MCM activity as long it remains bound to the complex.
What is the function of Geminin?
Geminin is a 25 kDa nuclear protein that functions by inhibiting DNA replication. During specific phases of the cell cycle, geminin is able to bind to Cdt1 protein and inhibits pre-RC formation.
What is the function of the CDC6 gene?
Entrez Gene Summary for CDC6 Gene. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication.
How is Cdc6 related to Meier Gorlin syndrome 5?
CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell cycle. Gene Ontology (GO) annotations related to this gene include nucleotide binding and kinase binding.
What are the diseases associated with the FCGR3A gene?
FCGR3A (Fc Fragment Of IgG Receptor IIIa) is a Protein Coding gene. Diseases associated with FCGR3A include Immunodeficiency 20and Herpes Zoster. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3and IgA-Producing B Cells in the Intestine.
What kind of immunodeficiency is MIM 615707?
Immunodeficiency 20 (IMD20) [MIM:615707]: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).