What are BALB c nu nu mice?

What are BALB c nu nu mice?

BALB/c Nude Mouse Details This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c nude. The animal lacks a thymus, is unable to produce T-cells, and is therefore immunodeficient. The control model for the BALB/c Nude Mouse is the BALB/c Heterozygous Mouse.

What does BALB c mice stand for?

BALB/c is an albino, immunodeficient inbred strain. BALB refers to Bagg Albino (inbred research mouse strain. Dr. Halsey J. Bagg who started breeding these mice back in the 1920s.

Why are BALB c mice used?

BALB/c mice are useful for research into both cancer and immunology. Most substrains have a “long reproductive life-span”, are noted for displaying high levels of anxiety and for being relatively resistant to diet-induced atherosclerosis, making them a useful model for cardiovascular research.

What is athymic?

Listen to pronunciation. (ay-THY-mik nood …) A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation.

What is NOD SCID mice?

The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD. NSG branded mice are among the most immunodeficient described to date. NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells.

Are BALB c mice inbred?

BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theiler’s murine encephalomyelitis virus.

How long do BALB c mice live?

Survival analysis shows quite higher longevity (median age: about 29 months) in this population when compared with other BALB/c strains.

Do BALB c mice have an immune system?

The structural and functional parameters of the immune system in BALB/c and C57Bl/6 mice differ under physiological conditions. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic activity of splenic NK cells.

Why are athymic mice?

A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the “nude” nickname.

What are athymic rats?

Athymic nude rats resemble nude mice in their lack of a normal thymus and functionally mature T cells. Nude rats develop T-like cells expressing CD3 and T-cell receptor (TCR) with increasing age.

What are SCID beige mice?

SCID-bg (scid/scid, beige/beige) is a strain of double-mutant mice with impaired lymphoid development and reduced natural killer (NK) cell activity.

Do SCID mice have microglia?

Despite absence of neuropathology and lack of microglial activation, microglial numerical density was significantly increased in SCID mice. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice.

Is the BALB / c nu / nu mouse affected by Con a?

Data are from Inoue et al. (2013) with permission. The above findings, showing that NK-CMC of Balb/c nu/nu mice are not affected by Con A, suggested that the effector cell may not be the classical NK effector cell. We tested the effect of cytotoxic anti-Thy 1.2 and anti-A-GM 1 treatment of effector cells in both NK-CMC and NK-LDCC.

Can a BALB / c nu / nu mouse get oophoritis?

Since 1977, investigators have elicited autoimmune oophoritis in normal BALB/c nu/nu mice by transfer of lymphoid cells from normal nu /+ littermates ( Table II ). More recently, this experimental approach has been used to investigate the pathogenetic basis of autoimmune diseases that follow D3TX.

How to get rid of brain tumor in mice?

Human brain tumor U87MG cells were subcutaneously inoculated into the right flank of each mouse (5 × 10 6 cells/0.1 ml/mouse). Around 3 days after this injection, the mice were orally administered ALA (30 mg/kg body weight, p.o.) and/or gefitinib (100 mg/kg body weight, p.o.).

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