How long does it take for Paxil to work for premature ejaculation?
After four weeks of this “as needed” regimen, the average time from vaginal penetration to ejaculation was 3.4 minutes with paroxetine and 0.5 minutes with placebo, a significant difference. No adverse effects were reported.
How long does it take for antidepressants to work for premature ejaculation?
These medications usually take five to 10 days to begin working. But it might take two to three weeks of treatment before you’ll see the full effect. If SSRIs don’t improve the timing of your ejaculation, your doctor might prescribe the tricyclic antidepressant clomipramine (Anafranil).
Can you take Paxil as needed for premature ejaculation?
Paroxetine appears to be a useful and well tolerated oral treatment for premature ejaculation on a daily or as needed basis. Paroxetine as needed was efficacious and not associated with adverse effects in our study. The lack of adverse effects may be associated with improved patient acceptance and compliance.
Does Paxil affect ejaculation?
It’s well known that Paxil has sexual side effects, including delayed ejaculation.
Does Paroxetine work immediately?
Paxil will not work immediately to help reduce your symptoms of panic disorder. Improvements are typically noticed within several days to weeks of starting your prescription, but it can be several months before you experience the full benefits of Paxil.
Why do SSRIs help treat early ejaculation?
The SSRIs block 5-HT reuptake, and these results in an increased 5-HT neurotransmission and activation of post-synaptic 5-HT receptors. SSRI-induced delayed ejaculation and anorgasmia is probably related to an increased central 5-HT neurotransmission and activation of postsynaptic 5-HT receptors (Olivier et al 1998).
Does Paroxetine cure premature ejaculation permanently?
Conclusions: Paroxetine hydrochloride appears to be a useful agent in the pharmacological treatment of premature ejaculation when administered on a chronic, an ‘on-demand’ basis following chronic treatment or initial ‘on demand’ basis.
How quickly can Paxil work?
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
When does Paxil peak?
Pharmacokinetics. Paroxetine is well-absorbed following oral administration. It has an absolute bioavailability of about 50%, with evidence of a saturable first pass effect. When taken orally, it achieves maximum concentration in about 6–10 hours and reaches steady-state in 7–14 days.